Fish oil supplements lower the risk of heart disease – but only for patients with the right genetic makeup

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Ye et al. examined data from 70,000 patients who participated in the UK biobank study. While approximately 11,000 participants were taking fish oil supplements, the rest of the participants were not.

The authors performed more than 64 million tests and found that the GJB2 gene appeared to be a key element of the equation. Participants with the AG genotype who took fish oil supplements had a decrease in their triglycerides, but participants with the AA genotype who took fish oil supplements did not. In fact, the AA genotype was actually associated with a slight increase in triglycerides.

Looking ahead, the researchers hope to learn more about how fish oil affects patients with cardiovascular disease – at least if the patients have the right genetic makeup.

“Personalizing and optimizing fish oil supplement recommendations based on a person’s unique genetic makeup can enhance our understanding of nutrition and lead to significant improvements in human health and wellbeing,” said Ye.

The full analysis can be read here.

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